High Quality Nicotinamide For Pharmaceutical Intermediates

Product Information

Uses of Niacinamide
(1) An amide derivative of vitamin B3 and a PARP inhibitor.
(2) Biochemical research: nicotinamide is a nutrient component of tissue culture medium; clinical drugs for vitamin B family, used in the prevention and treatment of pellagra and stomatitis, lingual inflammation and other diseases.
(3) Nicotinamide can be used in skin care products to prevent skin roughness, maintain skin cell health and promote skin whitening. Used in hair care can promote scalp blood circulation, healthy hair follicles, promote hair growth and prevent baldness.
(4) niacinamide and niacin can be used in most occasions, niacin is also generated in the animal body niacinamide, niacinamide water solubility is better than niacin, but easy to generate a complex with vitamin C and caking. When the body lacks niacinamide, it will get pellagra, so this product can prevent pellagra.
(5) It plays a role in the metabolism of protein and sugar, and can improve the nutrition of humans and animals. It can be used as a nutritional Additive in cosmetics. It is also used in medicine, food and feed additives.
Pharmaceutical Profile of Nicotinamide
Pharmacological Actions of Nicotinamide
Nicotinamide is a component of coenzyme I and coenzyme II, and becomes a coenzyme of many dehydrogenases. Lack of nicotinamide can affect the normal respiration and metabolism of cells and cause pellagra. Nicotinamide is easily absorbed in the gastrointestinal tract, and after absorption, it is distributed to the whole body tissues, metabolized by the liver, and only a small amount of it is excreted from the urine in its original form.
Pharmacokinetics
Nicotinamide is readily absorbed in the gastrointestinal tract and distributed to tissues throughout the body after absorption, with a half-life (t1/2) of about 45 minutes. Metabolized by the liver, only a small amount of the therapeutic dose is excreted in its original form from the urine.
Indications
1、It is mainly used for the prevention and treatment of pellagra, stomatitis and lingual inflammation.
2、It is used for the treatment of coronary heart disease, viral myocarditis, rheumatic heart disease and a few digitalis poisoning and other accompanying arrhythmias (most of them are applied after other drugs are ineffective).
3、It is mainly used in cardiovascular system:
(1) Preventing and controlling heart block and improving sinus node function; it can improve heart rate slowing and atrioventricular block caused by verapamil.
(2) Used in coronary heart disease, viral myocarditis, rheumatic heart disease and slow-type arrhythmia caused by digitalis poisoning.
Contraindications
Those who are allergic to this product.

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