High Purity Sorbitol for The Pharmaceutical Industry

Introduction of the product

Physical and chemical properties of Sorbitol
1.Existence form Sorbitol's main existence form is liquid and solid: liquid sorbitol is 50% or 70% colorless transparent aqueous solution; solid sorbitol appearance is white needle, flake or granular crystalline powder, some contain 0.5 or 1 molecule of water of crystallization.
2. Flavor and sweetness Sorbitol has unique flavor, cool and refreshing taste, and the sweetness is about 60% of the same concentration of sucrose.
3. Solubility and viscosity sorbitol is very soluble in water, slightly soluble in methanol, ethanol and acetic acid, etc. The solubility of sorbitol at 20 ℃ is 220g/100mL of water, sucrose is only 195g/100mL of water. Because of the solubility in water, sorbitol is not easy to crystallize in industrial production. Under the same conditions, the viscosity of sorbitol water solution is slightly lower than that of sucrose.
4. hygroscopicity and humectancy Sorbitol hygroscopicity is very big, hygroscopicity is much bigger than sucrose, slightly smaller than glycerol, in the air Chemicalbook gas relative humidity is bigger when it is very easy to absorb moisture caking; but γ crystalline type of sorbitol hygroscopicity is smaller. Extend the shelf life of the product.
5. Freezing point reduction Sorbitol aqueous solution will cause freezing point drop, applied to frozen food can avoid the appearance of ice slag, reduce the crystal suspension or precipitation precipitation, effectively improve the taste of the product.
6. Stability Sorbitol molecule does not contain reducing groups, chemical properties are relatively stable, non-combustible, non-volatile, acid and alkali resistance, not easily oxidized by air. Sorbitol's thermal stability is good; in certain reaction conditions, sorbitol can be dehydrated and oxidized, esterification, etherification and other reactions, in strong acid and alkali solution can also chelate various metal ions.
7. Osmotic pressure Sorbitol molecular weight is slightly larger than glucose, so the osmotic pressure is close to glucose, 1.88 times of sucrose. Higher osmotic pressure means that the resistance to microorganisms is correspondingly stronger, and it can be used to control microorganisms in fruit and vegetable sauces.
Sorbitol in the pharmaceutical industry
Sorbitol can be used as a raw material for the production of vitamin C; it can also be used as a raw material for syrups, injectable infusions, pharmaceutical pressed tablets, as a drug dispersant, filler, cryoprotectant, anticrystallization agent, stabilizer of traditional Chinese medicines, wetting agent, capsule plasticizer, sweetening agent, ointment matrix, etc. Barrett et al. synthesized a light-curing polyester by using acrylic acid as the dibasic acid and choosing sorbitol as the alcohol. In vitro cytotoxicity tests on Swiss albino murine 3T3 fibroblasts (SAFs) showed high cell survival.Teng et al. prepared six-armed star-shaped poly(L-lactic acid) s-PLLA as a controlled release drug carrier for hydrophobic drug molecules by ring-opening polymerization of l-lactic acid using sorbitol as an initiator and stannous caprylate as a catalyst.Maniganda et al. synthesized a lysosomal targeted drug delivery system to deliver the anticancer drug Adriamycin by introducing octaguanidine and tetrapeptide sequence lysosomal B (CAT B) using sorbitol backbone. In the synthesized material, the concentration of adriamycin released by DDS1 was higher in tumor tissues than in normal tissues and the synthesized product did not show any significant toxicity even at high concentrations.

Company information

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(1) Petrochemicals:Petroleum products is a generic term for a variety of commodities that are produced directly from petroleum or a portion of petroleum.Petrochemical use petroleum as the basic raw material.The petroleum industry has always been dominated by the production of petrol, paraffin and Fuel Oil for industrial boilers. One of the refining methods, catalytic cracking, is the use of heat, pressure and catalysts to crack heavy oils into lighter oils, mainly gasoline. 

(2)Polymers：Polymerisation is the process by which the repeating units that make up a polymer are linked together by covalent bonds.Polymers can exist in different states depending on the phase, conformation and arrangement of their molecular chains. The two main states are amorphous and crystalline. Polymers usually exist in a semi-crystalline form in which amorphous and crystalline phases coexist.